Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1.

@article{Nigrovic2007MastCC,
  title={Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1.},
  author={Peter A Nigrovic and Bryce A Binstadt and Paul A Monach and Alyssa Johnsen and Michael F. Gurish and Yoichiro Iwakura and C. Benoist and Diane Mathis and David M. Lee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 7},
  pages={
          2325-30
        }
}
Mast cells are immune sentinels that participate in the defense against bacteria and parasites. Resident within the joint, mast cells become activated in human rheumatoid arthritis and are implicated in the pathogenesis of experimental murine synovitis. However, their arthritogenic role remains undefined. Using a model of autoantibody-induced arthritis, we show that mast cells contribute to the initiation of inflammation within the joint by elaboration of IL-1. Mast cells become activated to… CONTINUE READING

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