Mast cells are required for experimental oral allergen-induced diarrhea.

  title={Mast cells are required for experimental oral allergen-induced diarrhea.},
  author={Eric B Brandt and Richard T. Strait and Dan D. Hershko and Quan Wang and Emily E. Muntel and Troy A Scribner and Nives Zimmermann and Fred D. Finkelman and Marc E Rothenberg},
  journal={The Journal of clinical investigation},
  volume={112 11},
Gastrointestinal allergic disorders represent a diverse spectrum of inflammatory diseases that are occurring with increasing incidence and severity. An essential question concerning these disorders is to determine the specific cells and mediators responsible for specific clinical manifestations. With this in mind, we developed a murine model of oral allergen-induced intestinal inflammation accompanied by strong Th2-associated humoral and cellular responses and focused on the immunopathogenesis… CONTINUE READING
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