Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy.

@article{Johansson2010MastCA,
  title={Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy.},
  author={Anna Johansson and Stina H{\"a}ggstr{\"o}m Rudolfsson and Peter Hammarsten and Sofia Halin and Kristian Pietras and Jonathan Jones and P{\"a}r Stattin and Lars Egevad and Torvald Granfors and Pernilla Wikstr{\"o}m and Anders Bergh},
  journal={The American journal of pathology},
  year={2010},
  volume={177 2},
  pages={1031-41}
}
Mast cells affect growth in various human tumors, but their role in prostate cancer (PC) is unclear. Here, we identify mast cells as independent prognostic markers in PC using a large cohort of untreated PC patients with a long follow-up. By analyzing mast cells in different tissue compartments, our data indicate that intratumoral and peritumoral mast cells have anti- opposed to protumor properties. Intratumoral mast cells negatively regulate angiogenesis and tumor growth, whereas peritumoral… CONTINUE READING

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