Mast cells are an important cellular source of tumour necrosis factor alpha in human intestinal tissue.

@article{Bischoff1999MastCA,
  title={Mast cells are an important cellular source of tumour necrosis factor alpha in human intestinal tissue.},
  author={Stephan C. Bischoff and Axel Lorentz and Silke Schwengberg and G Weier and Rudolf Raab and Michael P. Manns},
  journal={Gut},
  year={1999},
  volume={44 5},
  pages={643-52}
}
BACKGROUND Several inflammatory disorders of the intestine are characterised by enhanced expression of tumour necrosis factor alpha (TNF-alpha). Monocytes and macrophages have been suggested as a major cellular source of TNF-alpha in human gut, whereas mast cells, although known to be capable of producing TNF-alpha, have been poorly examined in this respect. AIMS To investigate whether human intestinal mast cells can produce TNF-alpha, and which factors regulate TNF-alpha production in these… CONTINUE READING

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