Mast cells and tumour angiogenesis: the tumor-mediated release of an endothelial growth factor from mast cells.

Exposure to tumour cells has previously been shown to induce mast cells to degranulate and release heparin. Isolated mast-cell granules were found to be mitogenic for endothelial cells in vitro. This effect was a property of mast-cell heparin, whose potency as a mitogen exceeded that of commercial heparins. The basis of this difference lay in the… CONTINUE READING