Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome.

@article{Piche2008MastCA,
  title={Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome.},
  author={Thierry Piche and M-C Saint-Paul and Raffaella Dainese and Eug{\'e}nia Marin{\'e}-Barjoan and Antonio Iannelli and Maite Lasa Montoya and J. F. Peyron and Dorota Czerucka and Faredj Ch{\'e}rikh and J{\'e}r{\^o}me Filippi and Albert Tran and Xavier A H{\'e}buterne},
  journal={Gut},
  year={2008},
  volume={57 4},
  pages={468-73}
}
BACKGROUND A subset of patients with irritable bowel syndrome (IBS) have an increased number of mast cells (MCs) in the colonic mucosa. Psychological factors are believed to contribute to the course of IBS. AIMS To examine associations between fatigue, depression and MCs of the colonic mucosa in IBS. METHODS Colonic biopsies were taken from 50 Rome II IBS patients, 21 healthy controls and 11 depressed/fatigued patients without IBS. The cellularity of the lamina propria was determined as the… CONTINUE READING

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