Mast cells and atopic dermatitis. Stereological quantification of mast cells in atopic dermatitis and normal human skin

@article{Damsgaard1997MastCA,
  title={Mast cells and atopic dermatitis. Stereological quantification of mast cells in atopic dermatitis and normal human skin},
  author={Tine Engberg Damsgaard and Anne Braae Olesen and Flemming Brandt S{\o}rensen and Kristian thestrup-pedersen and Peter Oluf Schi{\o}tz},
  journal={Archives of Dermatological Research},
  year={1997},
  volume={289},
  pages={256-260}
}
Stereological quantification of mast cell numbers was applied to sections of punch biopsies from lesional and nonlesional skin of atopic dermatitis patients and skin of healthy volunteers. We also investigated whether the method of staining and/or the fixative influenced the results of the determination of the mast cell profile numbers. The punch biopsies were taken from the same four locations in both atopic dermatitis patients and normal individuals. The locations were the scalp, neck and… Expand
Stereological quantification of lymphocytes in skin biopsies from atopic dermatitis patients.
TLDR
Stereological techniques to quantify the number of lymphocytes in skin biopsies are introduced and it is shown that a patient with clinically moderate AD has a considerable number ofymphocytes in the skin. Expand
Quantification of Mast Cells and Blood Vessels in the Skin of Patients With Cutaneous Mucinosis
TLDR
Although many clinical forms of mucinosis have been described, neither mast cell number nor vessel distribution seems to distinguish the 3 different forms studied here, and there was no significant difference in the numbers of mast cells or blood vessels between the 3 subgroups of cutaneous mucinosa. Expand
A Comparative Analysis of Mast Cell Quantification in Five Common Dermatoses: Lichen Simplex Chronicus, Psoriasis, Lichen Planus, Lupus, and Insect Bite/Allergic Contact Dermatitis/Nummular Dermatitis
TLDR
The study showed that the mast cell distribution pattern is different across the two methods of staining for the five aforesaid dermatoses, and the other important observation was the dendritic morphology of the mast cells. Expand
Skin Site Mast Cell Numbers Correlate with Rates of Nodular Growth, but Not Incidence, of Basal Cell Carcinoma
TLDR
It is suggested that MCs can promote the development and/or growth of BCC by contributing to epidermal thickening and hair follicle growth and processes that involve increased keratinocyte proliferation. Expand
Stereological quantification of mast cells in human synovium
Mast cells participate in both the acute allergic reaction as well as in chronic inflammatory diseases. Earlier studies have revealed divergent results regarding the quantification of mast cells inExpand
Levels of mast-cell growth factors in plasma and in suction skin blister fluid in adults with mastocytosis: correlation with dermal mast-cell numbers and mast-cell tryptase.
TLDR
Elevated levels of IL-6 could contribute to the fever, fatigue, and osteoporosis observed in patients with SM and becauseIL-6 is antiapoptotic for mast cells, IL- 6 could potentiate the biologic consequences of this disease. Expand
The role of Malassezia allergens and mast cells in atopic eczema
TLDR
The effect of the pH of AE skin on the allergenicity of Malassezia as well as the yeast’s interaction with mast cells will help to elucidate the pathogenic mechanisms of AE and could contribute to the development of new treatment strategies for AE patients sensitized to M. sympodialis. Expand
Eosinophils Increase Neuron Branching in Human and Murine Skin and In Vitro
TLDR
It is demonstrated that human atopic dermatitis skin has eosinophil granule proteins present in the same region as increased nerves, and a pathophysiological role for eOSinophils in cutaneous nerve growth in atopic skin conditions with neuronal symptoms such as itch is indicated. Expand
The treatment of atopic dermatitis with topical immunomodulators.
TLDR
Patients with AD have abnormal skin barrier function and epidermal lipid abnormalities, and current thinking, based on analysis of circulating lymphocytes and immunohistochemical and in situ hybridization studies of lesional skin, favors a biphasic model of causation. Expand
Mast Cells and Lipid Cross-Talk in Skin Inflammation
TLDR
A novel method of computer-assisted image analysis for in situ quantification of mast cells (MC) activation is described and quantitative parameters to measure skin remodeling in early-stage atopic dermatitis (eczema) are defined using a validated human AD-like mouse model. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 26 REFERENCES
Mast cell invasion of peripheral nerve in skin lesions of atopic dermatitis.
TLDR
The degranulation of mast cells within peripheral nerve bundles and edema of the nerve bundle may pay a role in provoking or aggravating itchiness of atopic dermatitis. Expand
Analysis of mast cell subpopulations (MCT, MCTC) in cutaneous inflammation using novel enzyme‐histochemical staining techniques
TLDR
The data suggest that disease‐dependent mast cell dynamics involve only MCT in cutaneous inflammation and that MCT numbers are controlled by distinct, disease‐specific local tissue factors. Expand
Formalin sensitivity and differential staining of mast cells in human dermis
TLDR
The human dermal mast cell population, therefore, displays heterogeneity with respect to formalin fixation sensitivity and alcian blue/safranin staining. Expand
Human cutaneous mast cells–a study of fixative and staining reactions in normal skin
TLDR
Alcian blue/safranin and fluorescein‐conjugated avidin were both superior to the other staining methods used and are recommended for optimal visualization and assessment of mast cells in human skin. Expand
Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation.
TLDR
Findings indicate that the mast cell is an important source of preformed cytokines and as such may contribute to the chronicity of the mucosal inflammation that characterizes allergic rhinitis. Expand
MAST CELL POPULATION IN HUMAN SKIN.
TLDR
It is felt it would be appropriate to accumulate figures concerning the number of mast cells in relation to age, race, and sex, and on their distribution according to regions of the body, in an attempt to find a standard by which variations from the normal may be detected and which may serve as an aid in the study of skin diseases. Expand
Two types of human mast cells that have distinct neutral protease compositions.
TLDR
The recognition of human mast cell types with distinct protease compositions suggests a higher level of complexity of humanmast cell-mediated reactions than heretofore appreciated. Expand
Human skin mast cells: their dispersion, purification, and secretory characterization.
TLDR
The sensitivity of skin mast cells to nonimmunologic stimulation clearly distinguishes them from mast cells of the lung and lymphoid tissues and provides evidence of functional heterogeneity within human mast cells. Expand
Biological properties of human skin mast cells
  • M. Church, S. El-Lati, Y. Okayama
  • Biology, Medicine
  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1991
TLDR
The morphological characteristics of degranulation are similar, suggesting that the distinct biochemical pathways merge into a common pathway before effecting degranulated mast cells. Expand
Human mast cell heterogeneity: histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli.
TLDR
It is proposed that the presence of functional receptor sites for neuropeptides and basic compounds on skin mast cells that are not present in mast cell populations from mucosal or lymphoid sources reflects a specialized role for these cells in vascular homeostasis. Expand
...
1
2
3
...