Mast cells acquire MHCII from dendritic cells during skin inflammation

  title={Mast cells acquire MHCII from dendritic cells during skin inflammation},
  author={Jan Dudeck and Anna Medyukhina and Julia Fr{\"o}bel and Carl-Magnus Svensson and Johanna Kotrba and Michael Gerlach and Ann-Christine Gradtke and Bernd A Schr{\"o}der and Stephan Speier and Marc Thilo Figge and Anne Dudeck},
  booktitle={The Journal of experimental medicine},
Mast cells (MCs) and dendritic cells (DCs) are essential innate sentinels populating host-environment interfaces. Using longitudinal intravital multiphoton microscopy of DCGFP/MCRFP reporter mice, we herein provide in vivo evidence that migratory DCs execute targeted cell-to-cell interactions with stationary MCs before leaving the inflamed skin to draining lymph nodes. During initial stages of skin inflammation, DCs dynamically scan MCs, whereas at a later stage, long-lasting interactions… CONTINUE READING
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