Mast cell transcriptional networks.

  title={Mast cell transcriptional networks.},
  author={Clifford M. Takemoto and Y Lee and Anil G. Jegga and Daniella Zablocki and Stephanie M. Brandal and Amir H. Shahlaee and Suming Huang and Ying Ye and Sivakumar Gowrisankar and Jimmy Huynh and Michael A. McDevitt},
  journal={Blood cells, molecules & diseases},
  volume={41 1},
Unregulated activation of mast cells can contribute to the pathogenesis of inflammatory and allergic diseases, including asthma, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. Absence of mast cells in animal models can lead to impairment in the innate immune response to parasites and bacterial infections. Aberrant clonal accumulation and proliferation of mast cells can result in a variety of diseases ranging from benign cutaneous mastocytosis to systemic mastocytosis… CONTINUE READING