Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study

@article{Rukwied2000MastCM,
  title={Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study},
  author={R. Rukwied and G. Lischetzki and F. Mcglone and G. Heyer and M. Schmelz},
  journal={British Journal of Dermatology},
  year={2000},
  volume={142}
}
  • R. Rukwied, G. Lischetzki, +2 authors M. Schmelz
  • Published 2000
  • Medicine
  • British Journal of Dermatology
  • While histamine is the crucial mediator of pruritus in type 1 allergic reactions, its role in atopic dermatitis (AD) is unclear. In this study, the role of mast cell mediators in protein extravasation and pruritus was evaluated using intradermal microdialysis. The microdialysis capillaries were used to apply the mast cell degranulating substance compound 48/80 (C48/80; 0·05%) or histamine (0·01%) and also to deliver H1‐blockers (cetirizine, 200 μg mL−1) in nine AD patients and nine controls… CONTINUE READING
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