Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study

@article{Rukwied2000MastCM,
  title={Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: a dermal microdialysis study},
  author={Roman Rukwied and Grischa Lischetzki and Francis McGlone and Gisela Heyer and Martin Schmelz},
  journal={British Journal of Dermatology},
  year={2000},
  volume={142}
}
While histamine is the crucial mediator of pruritus in type 1 allergic reactions, its role in atopic dermatitis (AD) is unclear. In this study, the role of mast cell mediators in protein extravasation and pruritus was evaluated using intradermal microdialysis. The microdialysis capillaries were used to apply the mast cell degranulating substance compound 48/80 (C48/80; 0·05%) or histamine (0·01%) and also to deliver H1‐blockers (cetirizine, 200 μg mL−1) in nine AD patients and nine controls… 
Neuromediators and inflammation
  • J. Ansel
  • Biology, Medicine
    Experimental dermatology
  • 2001
TLDR
It is proved that after H1 receptor blockade itch due to mast cell depletion is abolished in healthy subjects but not in patients suffering from atopic dermatitis, as well as other mediators, also released from mast cells, must be responsible for the itching in this disease.
Mast cell mediators other than histamine induced pruritus in atopic dermatitis patients – a dermal microdialysis study
  • M. Greaves
  • Medicine, Biology
    The British journal of dermatology
  • 2000
TLDR
In this issue, Schmelz and colleagues from Erlangen use dermal microdialysis to demonstrate reduced extravasation of protein from the microcirculation of the skin in atopic dermatitis patients in response to intradermal delivery of histamine and the chemical histamine liberator, compound 48/80.
Mast cell chymase is increased in chronic atopic dermatitis but not in psoriasis
TLDR
It is suggested that mast cell chymase may play an integral part in eliciting and maintaining cutaneous inflammation in AD but not in psoriasis, which enhances the skin’s permeability to allergens and microbes and thereby aggravates the eczema.
Neuronal sensitization for histamine-induced itch in lesional skin of patients with atopic dermatitis.
TLDR
The results suggest a decreased activation of peripheral pruriceptors in patients with atopic dermatitis, and the massively increased itch in lesional skin of patients with AD might be based on sensitization for itch in the spinal cord rather than in primary afferent neurons.
Pathophysiology of pruritus in atopic dermatitis: an overview
TLDR
This review highlights the recent knowledge of different mechanisms which may be involved in regulating pruritus in patients with AD potentially leading to new therapeutic applications for the treatment of itch in AD.
Neuroimmunological Mechanism of Pruritus in Atopic Dermatitis Focused on the Role of Serotonin
  • Kwangmi Kim
  • Medicine, Biology
    Biomolecules & therapeutics
  • 2012
TLDR
Clinical and experimental reports suggest the possibility that antipruritic effects of selective serotonin reuptake inhibitors in atopic dermatitis patients might be at least partly due to their suppressive effect on T cells.
Stigmasterol Alleviates Cutaneous Allergic Responses in Rodents
TLDR
Stigmasterol demonstrates significant potential as a molecule of interest in allergic skin disease therapy as well as suppressive effect on immunoglobulin E-mediated active cutaneous anaphylaxis, compound 48/80-induced pruritus, and irritant dermatitis induced by 12-O-tetradecanoylphorbol-13-acetate.
Histamine and antihistamines in atopic dermatitis.
TLDR
The role of histamine in AD and the efficacy of antihistamines in its treatment is assessed based on results of basic research and clinical studies.
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