Mast cell mediators in allergic inflammation and mastocytosis.

  title={Mast cell mediators in allergic inflammation and mastocytosis.},
  author={Mariana C. Castells},
  journal={Immunology and allergy clinics of North America},
  volume={26 3},
Mast cells possess an array of potent inflammatory mediators capable of inducing acute symptoms after cell activation, including urticaria, angioedema, bronchoconstriction, diarrhea, vomiting, hypotension, cardiovascular collapse, and death in few minutes. In contrast, mast cells can provide an array of beneficial mediators in the setting of acute infections, cardiovascular diseases, and cancer. The balance between the detrimental and beneficial roles of mast cells is not completely understood… CONTINUE READING
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