Mast cell-independent impairment of host defense and muscle contraction in T. spiralis-infected W/W(V) mice.

@article{Vallance2001MastCI,
  title={Mast cell-independent impairment of host defense and muscle contraction in T. spiralis-infected W/W(V) mice.},
  author={Bruce A Vallance and Patricia A Blennerhassett and Jan D. Huizinga and Stephen M. Collins},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2001},
  volume={280 4},
  pages={G640-8}
}
In response to nematode infection, the host presumably attempts to create an unfavorable environment to prevent larval penetration of the host and to expedite parasite expulsion from the gut. In this study, we have used W/W(V) mice with or without mast cells after bone marrow reconstitution (BMR-W/W(V)) to examine the role of mast cells in the host response. W/W(V), BMR-W/W(V), and wild-type (+/+) mice were infected with Trichinella spiralis. Infected W/W(V) mice exhibited less tissue damage… CONTINUE READING

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