Mast cell growth factor, a ligand for the receptor encoded by c-kit, affects the growth in culture of the blast cells of acute myeloblastic leukemia.

@article{Wang1991MastCG,
  title={Mast cell growth factor, a ligand for the receptor encoded by c-kit, affects the growth in culture of the blast cells of acute myeloblastic leukemia.},
  author={Chunjie Wang and P. Kaisa Koistinen and Gyong Seon Yang and Douglas E. Williams and S. D. Lyman and Mark D Minden and E A Mcculloch},
  journal={Leukemia},
  year={1991},
  volume={5 6},
  pages={493-9}
}
The c-kit proto-oncogene encodes a transmembrane receptor with a tyrosine kinase internal domain. C-kit has been mapped to the W locus in the mouse, and the gene encoding the ligand has been shown to be the product of the murine SI locus. Previous genetic studies have shown that the murine W and SI loci play important roles in the normal function of hemopoietic stem cells. As these stem cells have been identified as the origins of abnormal clones in acute myeloblastic leukemia (AML), a study… CONTINUE READING

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