Mast cell-derived mediators promote murine neutrophil effector functions.

  title={Mast cell-derived mediators promote murine neutrophil effector functions.},
  author={Fatma Doener and Anastasija Michel and Sebastian Reuter and Pamela Friedrich and Livia B{\"o}hm and Manfred Relle and Laura Codarri and Stefan Tenzer and Matthias Klein and Tobias Bopp and Edgar Schmitt and Hansjoerg Schild and Markus P Radsak and Christian Taube and M. Janna Stassen and Marc Becker},
  journal={International immunology},
  volume={25 10},
Mast cells are able to trigger life-saving immune responses in murine models for acute inflammation. In such settings, several lines of evidence indicate that the rapid and protective recruitment of neutrophils initiated by the release of mast cell-derived pro-inflammatory mediators is a key element of innate immunity. Herein, we investigate the impact of mast cells on critical parameters of neutrophil effector function. In the presence of activated murine bone marrow-derived mast cells… CONTINUE READING
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