Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice.

@article{Piliponsky2010MastCT,
  title={Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice.},
  author={Adrian M Piliponsky and C H Chen and Michele A. Grimbaldeston and Stacy M Burns-Guydish and Jonathan Hardy and Janet Kalesnikoff and Christopher H. Contag and Mindy Tsai and Stephen J. Galli},
  journal={The American journal of pathology},
  year={2010},
  volume={176 2},
  pages={926-38}
}
We used mast cell-engrafted genetically mast cell-deficient C57BL/6-Kit(W-sh/W-sh) mice to investigate the roles of mast cells and mast cell-derived tumor necrosis factor in two models of severe bacterial infection. In these mice, we confirmed findings derived from studies of mast cell-deficient WBB6F(1)-Kit(W/W-v) mice indicating that mast cells can promote survival in cecal ligation and puncture (CLP) of moderate severity. However, we found that the beneficial role of mast cells in this… CONTINUE READING

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