Mast cell degranulation requires N-ethylmaleimide-sensitive factor-mediated SNARE disassembly.

@article{Puri2003MastCD,
  title={Mast cell degranulation requires N-ethylmaleimide-sensitive factor-mediated SNARE disassembly.},
  author={Niti Puri and Michael J. Kruhlak and Sidney W Whiteheart and Paul A. Roche},
  journal={Journal of immunology},
  year={2003},
  volume={171 10},
  pages={
          5345-52
        }
}
Mast cells possess specialized granules that, upon stimulation of surface FcR with IgE, fuse with the plasma membrane, thereby releasing inflammatory mediators. A family of membrane fusion proteins called SNAREs, which are present on both the granule and the plasma membrane, plays a role in the fusion of these granules with the plasma membrane of mast cells. In addition to the SNAREs themselves, it is likely that the SNARE accessory protein, N-ethylmaleimide-sensitive factor (NSF), affects the… CONTINUE READING
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