Mast cell degranulation mediates bronchoconstriction via serotonin and not via renin release.

@article{Krop2010MastCD,
  title={Mast cell degranulation mediates bronchoconstriction via serotonin and not via renin release.},
  author={Manne Krop and Zeynep G{\"u}neş Oz{\"u}nal and Wenxia Chai and Ren{\'e} de Vries and Durk Fekkes and Angelique M. Bouhuizen and Ingrid M. Garrelds and Alexander Hj Danser},
  journal={European journal of pharmacology},
  year={2010},
  volume={640 1-3},
  pages={185-9}
}
To verify the recently proposed concept that mast cell-derived renin facilitates angiotensin II-induced bronchoconstriction bronchial rings from male Sprague-Dawley rats were mounted in Mulvany myographs, and exposed to the mast cell degranulator compound 48/80 (300 microg/ml), angiotensin I, angiotensin II, bradykinin or serotonin (5-hydroxytryptamine, 5-HT), in the absence or presence of the renin inhibitor aliskiren (10 micromol/l), the ACE inhibitor captopril (10 micromol/l), the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…