Mast cell degranulation induced by type 1 fimbriated Escherichia coli in mice.

@article{Malaviya1994MastCD,
  title={Mast cell degranulation induced by type 1 fimbriated Escherichia coli in mice.},
  author={Ravi Malaviya and Elaine A. Ross and Barbara A. Jakschik and Soman N. Abraham},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={93 4},
  pages={1645-53}
}
The strategic location of mast cells at the host-environment interface and their ability to release potent mediators of inflammation have suggested that these cells may play a pivotal role in host defense against bacterial infection. The ability of the opportunistic pathogen, Escherichia coli, to induce degranulation of mast cells obtained from the mouse peritoneum was investigated. We determined that unlike a mutant derivative deficient in the FimH subunit of the fimbriae or nonfimbriated E… CONTINUE READING
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