Mast cell degranulation breaks peripheral tolerance.

  title={Mast cell degranulation breaks peripheral tolerance.},
  author={Victor C. de Vries and Anna Wasiuk and Kathy A. Bennett and Melissa Jane Benson and Raul Elgueta and Thomas J Waldschmidt and Randolph J. Noelle},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  volume={9 10},
Mast cells (MC) have been shown to mediate regulatory T-cell (T(reg))-dependent, peripheral allograft tolerance in both skin and cardiac transplants. Furthermore, T(reg) have been implicated in mitigating IgE-mediated MC degranulation, establishing a dynamic, reciprocal relationship between MC and T(reg) in controlling inflammation. In an allograft tolerance model, it is now shown that intragraft or systemic MC degranulation results in the transient loss of T(reg) suppressor activities with the… CONTINUE READING