Mast cell amines and the oedema induced by zymosan and carrageenans in rats.

@article{Damas1986MastCA,
  title={Mast cell amines and the oedema induced by zymosan and carrageenans in rats.},
  author={Jacques Damas and G. Remacle-Volon},
  journal={European journal of pharmacology},
  year={1986},
  volume={121 3},
  pages={
          367-76
        }
}
Cimetidine and metiamide suppressed the paw swelling induced in rats by low doses of histamine while these H2 antagonists had little effect on the oedema induced by 100 micrograms of histamine and inhibited by mepyramine. When administered 0.5 h before the inflammagens, H2 antagonists reduced the oedema induced by zymosan and iota carrageenan; they had a slight effect on the oedema induced by lambda and kappa carrageenans and no effect on the oedema induced by compound 48/80. When administered… Expand
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It was concluded that kinins and 5‐HT contributed significantly to oedema formation during this period, and mepyramine and methysergide, at the doses used in the carrageenin experiments, completely antagonized histamine and5‐HT, respectively, and did not affect the skin responses of bradykinin. Expand
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