Mast Cells and Tumor Microenvironment

@inproceedings{Theoharides2010MastCA,
  title={Mast Cells and Tumor Microenvironment},
  author={Theoharis C Theoharides and Konstantinos-Dionysios Alysandratos and Asimenia Angelidou and Bodi Zhang},
  year={2010}
}
Abstract Increasing evidence indicates that a unique immune cell, the mast cell, accumulates in the stroma surrounding certain tumors, especially mammary and pancreatic adenocarcinoma, as well as melanoma. Many molecules secreted by mast cells could benefit the tumor in at least four ways: (1) angiogenin, heparin and vascular endothelial growth factor (VEGF), which induce neovascularization; (2) proteases that disrupt the surrounding matrix and facilitate metastases; (3) growth factors such as… CONTINUE READING

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