Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

@article{Lee2002MastCA,
  title={Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis},
  author={David M. Lee and Daniel S. Friend and Michael F. Gurish and Christophe Benoist and Diane Mathis and Michael B. Brenner},
  journal={Science},
  year={2002},
  volume={297},
  pages={1689 - 1692}
}
Previous studies have revealed that autoantibodies, complement components, and Fc receptors each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not known which cellular populations are responsive to these inflammatory signals. We find that two strains of mice deficient in mast cells, W/Wv and Sl/Sld, were resistant to development of joint inflammation and that susceptibility was restored in the W/Wv strain by mast cell engraftment. Thus, mast cells may… Expand
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