Mast Cell Activation Syndrome

@article{Frieri2015MastCA,
  title={Mast Cell Activation Syndrome},
  author={Marianne Frieri},
  journal={Clinical Reviews in Allergy \& Immunology},
  year={2015},
  volume={54},
  pages={353-365}
}
  • M. Frieri
  • Published 1 June 2018
  • Medicine
  • Clinical Reviews in Allergy & Immunology
Mast cell activation syndrome (MCAS) involves the skin, gastrointestinal, cardiovascular, respiratory, and neurologic systems, classified as primary, secondary, and idiopathic. Earlier criteria for MCAS diagnosis included episodic symptoms with mast cell mediators affecting two or more organ systems with urticaria, angioedema, flushing, nausea, vomiting, diarrhea, abdominal cramping, hypotensive syncope, tachycardia, wheezing, conjunctival injection, pruritus, nasal stuffiness, decrease in… 
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TLDR
The current understanding of the role that mast cells play in the development of pediatric gastrointestinal disorders, including eosinophilic esophagitis, functional dyspepsia, irritable bowel syndrome, celiac disease, inflammatory bowel disease, histologically negative appendicitis, Hirschsprung’s disease, intestinal neuronal dysplasia, and food protein-induced enterocolitis syndrome is summarized.
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References

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TLDR
Typical clinical symptoms, a substantial transient increase in serum total tryptase level or an increase in other mast cell derived mediators, such as histamine or PGD2 or their urinary metabolites, and a response of clinical symptoms to agents that attenuate the production or activities of mast cell mediators are included.
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TLDR
The use of the term ‘spectrum’ is proposed to highlight the main symptoms, useful diagnostic tests and treatment approaches associated with mast cell activation disorders and propose the use of c-kit mutation and clonal MC activation disorder.
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TLDR
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