Mast Cell Activation Syndrome
@article{Frieri2015MastCA, title={Mast Cell Activation Syndrome}, author={Marianne Frieri}, journal={Clinical Reviews in Allergy \& Immunology}, year={2015}, volume={54}, pages={353-365} }
Mast cell activation syndrome (MCAS) involves the skin, gastrointestinal, cardiovascular, respiratory, and neurologic systems, classified as primary, secondary, and idiopathic. Earlier criteria for MCAS diagnosis included episodic symptoms with mast cell mediators affecting two or more organ systems with urticaria, angioedema, flushing, nausea, vomiting, diarrhea, abdominal cramping, hypotensive syncope, tachycardia, wheezing, conjunctival injection, pruritus, nasal stuffiness, decrease in…
45 Citations
Mast Cell Activation Syndrome: A Primer for the Gastroenterologist
- MedicineDigestive Diseases and Sciences
- 2020
Gastroenterologists who become aware of mast cell activation syndrome can dramatically improve the quality of life for their patients who previously have been labeled with a functional gastrointestinal disorder.
Mast Cell Activation Disorder and Postural Orthostatic Tachycardia Syndrome: A Clinical Association
- MedicineJournal of the American Heart Association
- 2021
Laboratory findings suggesting MCA disorder were relatively common in patients diagnosed with POTS and who present with additional nonorthostatic gastrointestinal, cutaneous, and allergic symptoms, which favor MCA Disorder being considered in such cases.
Mast cell activation may explain many cases of chemical intolerance
- MedicineEnvironmental Sciences Europe
- 2021
Close correspondence between QEESI scores and symptom patterns for MCAS and TILT patients supports xenobiotic-driven mast cell activation and mediator release (i.e., MCAS) as a plausible unifying biological mechanism for CI/TILT, with profound implications for medicine, public health, and regulatory toxicology.
The Mast Cell Activation Syndrome: A Mini Review
- Medicine
- 2015
This review will present a brief history of the mast cell and its subsequent association with multiple clinical disease states, as well as the criteria needed to delineate and classify these disease states into categories.
Mastocytosis and Mast Cell Activation Disorders: Clearing the Air
- Medicine, BiologyInternational journal of molecular sciences
- 2021
The role of this review is to clarify the classification ofmast cell disorders, point to molecular aspects of mast cell signaling, elucidate underlying genetic defects, and provide approaches to targeted therapies that may benefit patients.
Drug desensitization in 17-year-old male with Mast Cell Activation Syndrome, pneumonia, and antibiotic hypersensitivities.
- Medicine, BiologyAME case reports
- 2017
This case demonstrates that desensitization protocols can be used in MCAS patients with noted hypersensitivities, and presented with pneumonia requiring treatment with ceftriaxone and azithromycin, both provided via desensItization protocols.
Mastocytosis: from a Molecular Point of View
- Medicine, BiologyClinical Reviews in Allergy & Immunology
- 2017
Mast cells (MCs) are physiologically activated by binding of stem cell factor (SCF) to the extracellular domains of the Kit receptor and lead to constitutive KIT activation even in the absence of its ligand SCF.
A Primer on Mast Cell Activation Disease for the Nurse Practitioner
- MedicineThe Journal for Nurse Practitioners
- 2021
The pathophysiology of anaphylaxis.
- Biology, MedicineThe Journal of allergy and clinical immunology
- 2017
The role of mast cells in pediatric gastrointestinal disease
- MedicineAnnals of gastroenterology
- 2019
The current understanding of the role that mast cells play in the development of pediatric gastrointestinal disorders, including eosinophilic esophagitis, functional dyspepsia, irritable bowel syndrome, celiac disease, inflammatory bowel disease, histologically negative appendicitis, Hirschsprung’s disease, intestinal neuronal dysplasia, and food protein-induced enterocolitis syndrome is summarized.
References
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Mast Cell Activation Syndrome: A Review
- MedicineCurrent Allergy and Asthma Reports
- 2012
Typical clinical symptoms, a substantial transient increase in serum total tryptase level or an increase in other mast cell derived mediators, such as histamine or PGD2 or their urinary metabolites, and a response of clinical symptoms to agents that attenuate the production or activities of mast cell mediators are included.
Spectrum of mast cell activation disorders
- MedicineExpert review of clinical immunology
- 2014
The use of the term ‘spectrum’ is proposed to highlight the main symptoms, useful diagnostic tests and treatment approaches associated with mast cell activation disorders and propose the use of c-kit mutation and clonal MC activation disorder.
Prevention of anaphylaxis related to mast cell activation syndrome with omalizumab.
- MedicineAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
- 2012
Mast cell activation syndrome masquerading as agranulocytosis.
- MedicineMilitary medicine
- 2012
Mast cell activation syndrome should be considered in otherwise idiopathic agranulocytosis presenting with comorbidities best explained by MC mediator release, and different presentations of different MCAS patients reflect elaboration of different mediators likely consequent to different Kit mutations.
Expanding spectrum of mast cell activation disorders: monoclonal and idiopathic mast cell activation syndromes.
- Medicine, BiologyClinical therapeutics
- 2013
Evaluation of Mast Cell Activation Syndromes: Impact of Pathology and Immunohistology
- Medicine, BiologyInternational Archives of Allergy and Immunology
- 2012
When the activating point mutant KIT D816V is detectable but criteria for diagnosis of mastocytosis are not completely met, a so-called (mono)clonal MCAS as a subvariant of primary MCAS should be diagnosed.
Mast cell activation syndrome: Proposed diagnostic criteria.
- MedicineThe Journal of allergy and clinical immunology
- 2010
Clinical, biological, and molecular characteristics of clonal mast cell disorders presenting with systemic mast cell activation symptoms.
- Medicine, BiologyThe Journal of allergy and clinical immunology
- 2010
Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal
- Medicine, BiologyInternational Archives of Allergy and Immunology
- 2011
Criteria for diagnosing MCA and related disorders are defined by robust and generally applicable criteria and should assist in the identification and diagnosis of patients with MCAS, and in avoiding misdiagnoses or overinterpretation of clinical symptoms in daily practice.
Systemic sclerosis. The role of the mast cell and cytokines.
- Medicine, BiologyAnnals of allergy
- 1992
The allergist-immunologist may be the first physician to identify this insidious condition, since patients may present with cutaneous changes, swelling, pruritus, dyspnea, and with obstructive and restrictive findings on pulmonary function testing, or gastrointestinal symptoms, mimicking gastrointestinal hypersensitivity.