Mast Cell “Densities” in Vascular Proliferations: A Preliminary Study of Pyogenic Granuloma, Portwine Stain, Cavernous Hemangioma, Cherry Angioma, Kaposi's Sarcoma, and Malignant Hemangioendothelioma

@article{Hagiwara1999MastC,
  title={Mast Cell “Densities” in Vascular Proliferations: A Preliminary Study of Pyogenic Granuloma, Portwine Stain, Cavernous Hemangioma, Cherry Angioma, Kaposi's Sarcoma, and Malignant Hemangioendothelioma},
  author={Keisuke Hagiwara and Noor Mohammad Khaskhely and Hiroshi Uezato and Shigeo Nonaka},
  journal={The Journal of Dermatology},
  year={1999},
  volume={26}
}
The “densities” of mast cells (MCs) in six kinds of vascular proliferation, pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma (MHE), measured per mm2 were studied using respective specimens prepared with tryptase stain and a personal computer. The average densities of MCs in pyogenic granuloma and MHE were 103.5 ± 25.2/mm2 (n=10) and 106.3 ± 40.2/mm2 (n=10) [mean ± standard deviation (SD)]; that in normal skin was 6.85… 

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References

SHOWING 1-10 OF 22 REFERENCES

Mast cells in angiolipomas and hemangiomas of human skin: are they important for angiogenesis?

The results suggest that MC may not play an essential, early role in the proliferation of blood vessels in angiolipomas and hemangiomas, but rather may be related to maturation of blood Vessels in these tumors.

Cutaneous Malignant Hemangioendothelioma: Clinical and Histopathological Observations of Nine Patients and a Review of the Literature

Nine patients with cutaneous malignant hemangioendothelioma (CMHE) were reported in Okinawa, elderly, between 75 and 93 years of age, and one has survived and the prognosis was poor.

Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma.

It is found that a potent angiogenic and mitogenic polypeptide, basic fibroblast growth factor (bFGF), is localized to the majority of mast cells from normal skin and lung and in tissue samples characterized by fibrosis, hyperplasia, and neovascularization, suggesting that mast cells may contribute to these pathological conditions by releasing this polypePTide.

Angiosarcoma of the face and scalp, prognosis and treatment

72 patients with angiosarcoma of the face and scalp have been analyzed with respect of various prognostic factors and the effects of different treatment regimes, finding the overall poor prognosis and the apparent eradication of the local skin disease were poor.

Human mast cells stimulate vascular tube formation. Tryptase is a novel, potent angiogenic factor.

The results suggest that mast cells act at sites of new vessel formation by secreting tryptase, which then functions as a potent and previously unrecognized angiogenic factor.

Mast cells and atopic dermatitis. Stereological quantification of mast cells in atopic dermatitis and normal human skin

Using stereological techniques, this study indicated that mast cells might participate in the inflammatory process in skin leading to atopic dermatitis.

MAST CELL POPULATION IN HUMAN SKIN.

It is felt it would be appropriate to accumulate figures concerning the number of mast cells in relation to age, race, and sex, and on their distribution according to regions of the body, in an attempt to find a standard by which variations from the normal may be detected and which may serve as an aid in the study of skin diseases.

Mast cell granules cause proliferation of human microvascular endothelial cells.

A demonstration of mast cell granule-induced endothelial proliferation suggests that the mast cell may be of importance in the process of angiogenesis.

Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via the Fc epsilon RI. Role for mast cell-derived transforming growth factor beta and tumor necrosis factor alpha

It is demonstrated that IgE-dependent mouse mast cell activation can induce a transient and marked increase in steady state levels of type alpha-1 (I) collagen mRNA in dermal fibroblasts and that mast cell-derived TGF-beta 1 and TNF-alpha importantly contribute to this effect.