Mast Cell “Densities” in Vascular Proliferations: A Preliminary Study of Pyogenic Granuloma, Portwine Stain, Cavernous Hemangioma, Cherry Angioma, Kaposi's Sarcoma, and Malignant Hemangioendothelioma

  title={Mast Cell “Densities” in Vascular Proliferations: A Preliminary Study of Pyogenic Granuloma, Portwine Stain, Cavernous Hemangioma, Cherry Angioma, Kaposi's Sarcoma, and Malignant Hemangioendothelioma},
  author={Keisuke Hagiwara and Noor Mohammad Khaskhely and Hiroshi Uezato and Shigeo Nonaka},
  journal={The Journal of Dermatology},
The “densities” of mast cells (MCs) in six kinds of vascular proliferation, pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma (MHE), measured per mm2 were studied using respective specimens prepared with tryptase stain and a personal computer. The average densities of MCs in pyogenic granuloma and MHE were 103.5 ± 25.2/mm2 (n=10) and 106.3 ± 40.2/mm2 (n=10) [mean ± standard deviation (SD)]; that in normal skin was 6.85… 

Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors

It is suggested that mast cells may play an important role in neovascularization of canine cutaneous vascular and mammary neoplasm and with clinical outcomes and prognosis in these neoplasms.

Cutaneous Vascular Hyperplasias

Angiolymphoid hyperplasia with eosinophilia (AHE) was first described by Wells and Whimster in 1969 but it later became clear that the entities are different, and currently most authors believe that AHE and Kimura’s disease are two separate entities.

Immunohistological distribution of stem cell factor and kit receptor in angiosarcoma.

The results suggest that tumor cell-derived stem cell factor may play a role in the increased number of mast cells, via the kit receptor, which may contribute to the proliferation of tumor cells, leading to the progression of angiosarcoma.

Phacomatosis Pigmentovascularis Type IIb Associated with Sturge‐Weber Syndrome and Pyogenic Granuloma

A case of phacomatosis pigmentovascularis (PPV) in a 6‐year‐old girl with Sturge‐Weber syndrome, pyogenic granuloma, and other complications is described, indicating that MCs are closely associated with angiogenesis in pyogenic Granuloma.

A study of the pathogenesis of Rosacea: how angiogenesis and mast cells may participate in a complex multifactorial process

Microvessels density (MVD) and total vascular area (TVA) in addition to multiple morphologic characteristics of microvessels and also mast cells (MCs) number are evaluated in involved and clinically uninvolved skin of Rosacea to evaluate the relationship between angiogenesis, MCs number and disease clinicopathological data.

Oral pyogenic granuloma: a review.

Because of the high frequency of pyogenic granuloma in the oral cavity, especially during pregnancy, and necessity for proper diagnosis and treatment, a complete review of published information and investigations about this lesion, in addition to knowledge about new approaches for its treatment is presented.

C-Kit (CD117) Expression in AIDS-Related, Classic, and African Endemic Kaposi Sarcoma

It is indicated that c-kit expression in lesional cells can be detected by immunohistochemistry in different epidemiologic forms and histologic stages of KS.

Cherry hemangioma in the scalp

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Superficial arteriovenous hemangioma of the oral cavity.

  • A. BarrettP. Speight
  • Medicine
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • 2000
The etiology of AH is uncertain; endocrine and inflammatory stimuli may activate an underlying vascular malformation; some lesions, especially those in younger patients, may be true hamartomas.

Hemangioma rubi no couro cabeludo

This work demonstrates the high frequency of Cherry hemangioma in the scalp by noting that in a sample of 171 patients (85 men and 86 women) the author noted that 123 (72%) had CH inThe scalp.



Mast cells in angiolipomas and hemangiomas of human skin: are they important for angiogenesis?

The results suggest that MC may not play an essential, early role in the proliferation of blood vessels in angiolipomas and hemangiomas, but rather may be related to maturation of blood Vessels in these tumors.

Cutaneous Malignant Hemangioendothelioma: Clinical and Histopathological Observations of Nine Patients and a Review of the Literature

Nine patients with cutaneous malignant hemangioendothelioma (CMHE) were reported in Okinawa, elderly, between 75 and 93 years of age, and one has survived and the prognosis was poor.

Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma.

It is found that a potent angiogenic and mitogenic polypeptide, basic fibroblast growth factor (bFGF), is localized to the majority of mast cells from normal skin and lung and in tissue samples characterized by fibrosis, hyperplasia, and neovascularization, suggesting that mast cells may contribute to these pathological conditions by releasing this polypePTide.

Angiosarcoma of the face and scalp, prognosis and treatment

72 patients with angiosarcoma of the face and scalp have been analyzed with respect of various prognostic factors and the effects of different treatment regimes, finding the overall poor prognosis and the apparent eradication of the local skin disease were poor.

Human mast cells stimulate vascular tube formation. Tryptase is a novel, potent angiogenic factor.

The results suggest that mast cells act at sites of new vessel formation by secreting tryptase, which then functions as a potent and previously unrecognized angiogenic factor.

Mast cells and atopic dermatitis. Stereological quantification of mast cells in atopic dermatitis and normal human skin

Using stereological techniques, this study indicated that mast cells might participate in the inflammatory process in skin leading to atopic dermatitis.


It is felt it would be appropriate to accumulate figures concerning the number of mast cells in relation to age, race, and sex, and on their distribution according to regions of the body, in an attempt to find a standard by which variations from the normal may be detected and which may serve as an aid in the study of skin diseases.

Mast cell granules cause proliferation of human microvascular endothelial cells.

A demonstration of mast cell granule-induced endothelial proliferation suggests that the mast cell may be of importance in the process of angiogenesis.

Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via the Fc epsilon RI. Role for mast cell-derived transforming growth factor beta and tumor necrosis factor alpha

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