Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.

@article{Lemos2000MastAC,
  title={Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.},
  author={Catarina L. Lemos and Paula C{\'i}ntia Machado Sampaio and Helder Maiato and Madalena M. Costa and L. V. Omel'yanchuk and Vasco Liberal and Claudio E Sunkel},
  journal={The EMBO journal},
  year={2000},
  volume={19 14},
  pages={3668-82}
}
Through mutational analysis in Drosopjila we have identified the gene multiple asters (mast), which encodes a new 165 kDa protein. mast mutant neuroblasts are highly polyploid and show severe mitotic abnormalities including the formation of mono- and multi-polar spindles organized by an irregular number of microtubule-organizing centres of abnormal size and shape. The mast gene product is evolutionarily conserved since homologues were identified from yeast to man, revealing a novel protein… CONTINUE READING
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