Massive telomere loss is an early event of DNA damage-induced apoptosis.

@article{Ramirez2003MassiveTL,
  title={Massive telomere loss is an early event of DNA damage-induced apoptosis.},
  author={R V Santana Ramirez and Julia Carracedo and Rosario Jimenez and Andr{\'e}s Canela and Elo{\'i}sa Herrera and Pedro Aljama and Maria A Blasco},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 2},
  pages={836-42}
}
Chromosomal stability and cell viability require a proficient telomeric end-capping function. In particular, telomere dysfunction because of either critical telomere shortening or because of mutation of telomere-binding proteins results in increased apoptosis and/or cell arrest. Here, we show that, in turn, DNA damage-induced apoptosis results in a dramatic telomere loss. In particular, using flow cytometry for simultaneous detection of telomere length and apoptosis, we show that cells… CONTINUE READING

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