Massive reduction of urea transporters in remnant kidney and brain of uremic rats.

@article{Hu2000MassiveRO,
  title={Massive reduction of urea transporters in remnant kidney and brain of uremic rats.},
  author={Ming Chang Hu and Lise Bankir and Sandrine Michelet and Germain Rousselet and Marie Marcelle Trinh-Trang-Tan},
  journal={Kidney international},
  year={2000},
  volume={58 3},
  pages={1202-10}
}
BACKGROUND The facilitated urea transporters (UT), UT-A1, UT-A2, and UT-B1, are involved in intrarenal recycling of urea, an essential feature of the urinary concentrating mechanism, which is impaired in chronic renal failure (CRF). In this study, the expression of these UTs was examined in experimentally induced CRF. METHODS The abundance of mRNA was measured by Northern analysis and that of corresponding proteins by Western blotting in rats one and five weeks after 5/6 nephrectomy (Nx… CONTINUE READING