Massive liver replacement by transplanted hepatocytes in the absence of exogenous growth stimuli in rats treated with retrorsine.

@article{Laconi2001MassiveLR,
  title={Massive liver replacement by transplanted hepatocytes in the absence of exogenous growth stimuli in rats treated with retrorsine.},
  author={Sergio Laconi and Sara Pillai and P Porcu and David A. Shafritz and Paolo Pani and Ezio Laconi},
  journal={The American journal of pathology},
  year={2001},
  volume={158 2},
  pages={771-7}
}
A strategy for hepatocyte transplantation was recently developed whereby massive replacement of the recipient liver is achieved after a combined treatment with retrorsine, a pyrrolizidine alkaloid, and partial hepatectomy. We now investigated whether liver repopulation could occur in this animal model in the absence of any exogenous growth stimuli (eg, partial hepatectomy) for the transplanted cells. Dipeptidyl-peptidase type IV-deficient (DPPIV-) rats were used as recipients. Rats were given… CONTINUE READING