Massive liver growth in mice induced by systemic interleukin 6 administration.

@article{Zimmers2003MassiveLG,
  title={Massive liver growth in mice induced by systemic interleukin 6 administration.},
  author={Teresa A. Zimmers and Iain H Mckillop and R. H. Pierce and Joo-Yeon Yoo and Leonidas G. Koniaris},
  journal={Hepatology},
  year={2003},
  volume={38 2},
  pages={326-34}
}
The multifunctional cytokine interleukin 6 (IL-6) is expressed in a wide variety of disease states and pathologic processes. Mice deficient in IL-6 display abnormal and delayed liver regeneration and repair. Currently, IL-6 is thought to influence liver growth indirectly by priming hepatocytes to respond to growth factors such as hepatocyte growth factor (HGF) by inducing expression of HGF and by inhibiting hepatocyte apoptosis, as distinct from the direct mitotic effects of IL-6 on myeloid and… CONTINUE READING