Massive lineage replacements and cryptic outbreaks of Salmonella Typhi in eastern and southern Africa

Abstract

A new large-scale study reports the whole-genome sequences of nearly 2,000 Salmonella enterica serovar Typhi (S. Typhi) strains collected from 63 countries. A recent and dominant multidrug-resistant (MDR) lineage originating from South Asia, which is supplanting a bulk of ancestral drug-sensitive strains, is identified; the success of this lineage is likely driven by plasmid acquisitions and the chromosomal integration of resistance-conferring genes.

DOI: 10.1038/ng.3318

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Cite this paper

@article{Wirth2015MassiveLR, title={Massive lineage replacements and cryptic outbreaks of Salmonella Typhi in eastern and southern Africa}, author={Thierry Wirth}, journal={Nature Genetics}, year={2015}, volume={47}, pages={565-567} }