Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition.

@article{Chakrabarty2010MassiveGI,
  title={Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition.},
  author={Paramita Chakrabarty and Karen R. Jansen-West and Amanda Beccard and Carolina Ceballos-Diaz and Yona R Levites and C. Verbeeck and Abba Chedi Zubair and D. J. H. Dickson and Todd E Golde and Pritam Das},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2010},
  volume={24 2},
  pages={548-59}
}
Proinflammatory stimuli, after amyloid beta (Abeta) deposition, have been hypothesized to create a self-reinforcing positive feedback loop that increases amyloidogenic processing of the Abeta precursor protein (APP), promoting further Abeta accumulation and neuroinflammation in Alzheimer's disease (AD). Interleukin-6 (IL-6), a proinflammatory cytokine, has been shown to be increased in AD patients implying a pathological interaction. To assess the effects of IL-6 on Abeta deposition and APP… CONTINUE READING

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