Massive gene duplication event among clinical isolates of the Mycobacterium tuberculosis W/Beijing family.

@article{Domenech2010MassiveGD,
  title={Massive gene duplication event among clinical isolates of the Mycobacterium tuberculosis W/Beijing family.},
  author={Pilar Domenech and Ga{\"e}lle S. Kolly and Lizbel Esperanza Le{\'o}n-Sol{\'i}s and Ashley Fallow and Michael B. Reed},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 18},
  pages={4562-70}
}
As part of our effort to uncover the molecular basis for the phenotypic variation among clinical Mycobacterium tuberculosis isolates, we have previously reported that isolates belonging to the W/Beijing lineage constitutively overexpress the DosR-regulated transcriptional program. While generating dosR knockouts in two independent W/Beijing sublineages, we were surprised to discover that they possess two copies of dosR. This dosR amplification is part of a massive genomic duplication spanning… CONTINUE READING
23 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…