Massive expansion and functional divergence of innate immune genes in a protostome

@article{Zhang2015MassiveEA,
  title={Massive expansion and functional divergence of innate immune genes in a protostome},
  author={Linlin Zhang and L. Li and Ximing Guo and G. Litman and Larry J Dishaw and Guofan Zhang},
  journal={Scientific Reports},
  year={2015},
  volume={5}
}
The molecules that mediate innate immunity are encoded by relatively few genes and exhibit broad specificity. Detailed annotation of the Pacific oyster (Crassostrea gigas) genome, a protostome invertebrate, reveals large-scale duplication and divergence of multigene families encoding molecules that effect innate immunity. Transcriptome analyses indicate dynamic and orchestrated specific expression of numerous innate immune genes in response to experimental challenge with pathogens, including… Expand
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  • Ximing Guo, S. Ford
  • Biology, Medicine
  • Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2016
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