Massive expansion and functional divergence of innate immune genes in a protostome

  title={Massive expansion and functional divergence of innate immune genes in a protostome},
  author={Linlin Zhang and Li Li and Ximing Guo and Gary W. Litman and Larry J Dishaw and Guofan Zhang},
  booktitle={Scientific reports},
The molecules that mediate innate immunity are encoded by relatively few genes and exhibit broad specificity. Detailed annotation of the Pacific oyster (Crassostrea gigas) genome, a protostome invertebrate, reveals large-scale duplication and divergence of multigene families encoding molecules that effect innate immunity. Transcriptome analyses indicate dynamic and orchestrated specific expression of numerous innate immune genes in response to experimental challenge with pathogens, including… CONTINUE READING
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