Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

@article{Embretson1993MassiveCI,
  title={Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS},
  author={Janet Embretson and Mary L. Zupancic and Jorge L. Ribas and Alien Burke and Paul Racz and Klara Tenner-Racz and Ashley T Haase},
  journal={Nature},
  year={1993},
  volume={362},
  pages={359-362}
}
ANIMAL and human lentiviruses elude host defences by establishing covert infections and eventually cause disease through cumulative losses of cells that die with activation of viral gene expression1–5. We used polymerase chain reaction in situ double-label methods6,7 to determine how many CD4+ lymphocytes are latently infected by human immunodeficiency virus (HIV) in patient lymph nodes and whether the pool of infected cells is large enough to account for immune depletion through continual… CONTINUE READING
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