Massive carbamazepine overdose: clinical and pharmacologic observations in five episodes.

@article{Weaver1988MassiveCO,
  title={Massive carbamazepine overdose: clinical and pharmacologic observations in five episodes.},
  author={Donald F. Weaver and Peter R Camfield and Alexander Fraser},
  journal={Neurology},
  year={1988},
  volume={38 5},
  pages={755-9}
}
We report five episodes of carbamazepine (CBZ) intoxication in four patients. Clinically, there were four distinct stages: I--coma, seizures (CBZ levels more than 25 micrograms/ml [105 mumol/l]); II--combativeness, hallucinations, choreiform movements (15 to 25 micrograms/ml [65 to 105 mumol/l]); III--drowsiness, ataxia (11 to 15 micrograms/ml [45 to 65 mumol/l]); and IV--potentially catastrophic relapse (less than 11 micrograms/ml [45 mumol/l]). Pharmacokinetic studies revealed a prolongation… CONTINUE READING