Massive activation of immune cells with an intact T cell repertoire in acute human immunodeficiency virus syndrome.

@article{Cossarizza1995MassiveAO,
  title={Massive activation of immune cells with an intact T cell repertoire in acute human immunodeficiency virus syndrome.},
  author={Andrea Cossarizza and Claudio Ortolani and Cristina Mussini and Vanni Borghi and Giovanni Guaraldi and Nicola Mongiardo and E Bellesia and Maria Grazia Franceschini and B De Rienzo and Claudio Franceschi},
  journal={The Journal of infectious diseases},
  year={1995},
  volume={172 1},
  pages={105-12}
}
In 8 patients with symptomatic, acute primary infection with human immunodeficiency virus (HIV), a dramatic and persistent decrease in CD4+ lymphocytes was seen, accompanied by a marked increase in activated/memory CD8+ T cells (CD38+, CD45R0+, HLA-DR+, with high amounts of cell adhesion molecules), which represented most circulating lymphocytes, but no gross alterations in V beta T cell repertoire. Extremely high plasma levels of proinflammatory cytokines were observed. Three patients were… CONTINUE READING

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