Massive Ibuprofen Ingestion with Survival

@article{Seifert2000MassiveII,
  title={Massive Ibuprofen Ingestion with Survival},
  author={Steven A Seifert and Abram Bronstein and T McGuire},
  journal={Journal of Toxicology: Clinical Toxicology},
  year={2000},
  volume={38},
  pages={55 - 57}
}
Objective: To report a massive, 100 g ibuprofen ingestion in an adolescent, with survival. Case Report: The patient developed coma, metabolic acidosis, and mild thrombocytopenia, but improved rapidly with supportive care. Renal function remained normal and no gastrointestinal bleeding occurred. Conclusions: Massive ingestion of ibuprofen may result in a variable picture with some elements of significant toxicity, but supportive care usually results in survival without sequelae. 
Serious toxicity in a young child due to ibuprofen.
TLDR
An 18-month-old male presented to the emergency department (ED) for evaluation of lethargy and apnea and was extubated the next morning with a 30-second tonic-clonic seizure.
A report of two deaths from massive ibuprofen ingestion
TLDR
2 cases of ibuprofen overdose characterized by cardiovascular collapse, acidosis, and hypothermia despite the use of vasopressors and renal replacement therapy are described.
Ibuprofen plasma concentration profile in deliberate ibuprofen overdose with circulatory depression treated with therapeutic plasma exchange: a case report
TLDR
This is the first report of a severe ibuprofen-mono intoxication treated with TPE and providing serial IPCs over a period of five days, indicating an estimated fivefold overall-elimination half-life of 17.2 h.
Lactic acidosis and multisystem organ failure following ibuprofen overdose requiring haemodialysis
TLDR
Early intervention with CRRT may reverse acidosis, stabilise haemodynamics and halt secondary organ failure in a 17-year-old man admitted to the paediatric intensive care unit following an intentional ingestion of unknown substances.
Nonsteroidal Anti-Inflammatory Drug Toxicity in Children: A Clinical Review
Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most widely used classes of medications in children. Despite a reported positive safety profile, NSAIDs have been associated with
Nonsteroidal Anti-Inflammatory Drug Toxicity in Children: A Clinical Review
TLDR
Most children with NSAID overdoses are asymptomatic and should be managed conservatively, whereas a small number may present with severe symptoms, which is why strategies for their clinical evaluation and management are important.
An overview of clinical pharmacology of Ibuprofen.
TLDR
The main pharmacological effects, therapeutical applications and adverse drug reactions, drug-drug interactions and food drug interactions of ibuprofen that have been reported especially during the last 10 years are summarized.
Pediatric Poisonings: The Risk of Over-the-Counter Pharmaceuticals.
TLDR
Nonprescription medications, including acetaminophen and ibuprofen, are among the most commonly used pharmaceuticals across all age groups and there is an associated risk for therapeutic misuse, intentional misuse, and even abuse.
Ibuprofen-induced hypersensitivity syndrome.
  • R. Nanau, M. Neuman
  • Medicine
    Translational research : the journal of laboratory and clinical medicine
  • 2010
...
...

References

SHOWING 1-10 OF 12 REFERENCES
Acute oliguric renal failure due to ibuprofen overdose.
TLDR
A patient who had acute oliguric renal failure after ingesting a single large overdose of ibuprofen had no predisposing underlying disease, and subsequently had complete resolution of renal failure.
Acute oliguric renal failure due to ibuprofen overdose.
TLDR
A patient who had acute oliguric renal failure after ingesting a single large overdose of ibuprofen had no predisposing underlying disease, and subsequently had complete resolution of renal failure.
Acute Poisoning with Ibuprofen
TLDR
The data suggest that ibuprofen is of low toxicity in acute overdose and that therapy used should be supportive only.
Ibuprofen overdose in adults.
A prospective study of 63 ibuprofen overdose cases in adults (14 years or older) reported to the Rocky Mountain Poison and Drug Center between March 1987 and February 1988 was done to determine the
Ibuprofen overdose: 126 cases.
TLDR
In this study of ibuprofen overdose, symptoms developed in 19% of patients (24 of 126)--in 7% of children (6 of 88) and in 47% of adults (18 of 38)--in both the symptomatic and asymptomatic groups.
Tissue distribution of ibuprofen in a fatal overdose.
A 26-year-old white man was found dead near his home. The decedent had had a history of ibuprofen overdose and had recently received a physician's order for 800 mg ibuprofen every 4 h for back pain.
The Relationship between Plasma Ibuprofen Concentrations and Toxicity in Acute Ibuprofen Overdose
TLDR
Analysis of a larger information base utilizing similar methodology could, by increasing the statistical power of the resultant model, provide a useful means of predicting ibuprofen toxicity.
Acute intoxication due to ibuprofen overdose.
TLDR
A male patient ingested a single overdose of ibuprofen and developed severe metabolic acidosis, acute renal failure, acute liver-cell injury, acute cholestasis, and thrombocytopenia and had complete resolution of multiple organ failure.
Ibuprofen overdose
...
...