Massive CNS monocytic infiltration at autopsy in an alemtuzumab-treated patient with NMO

@inproceedings{Gelfand2014MassiveCM,
  title={Massive CNS monocytic infiltration at autopsy in an alemtuzumab-treated patient with NMO},
  author={Jeffrey M Gelfand and Jennifer Cotter and Jeffrey Klingman and Eric H. Huang and Bruce A. C. Cree},
  booktitle={Neurology(R) neuroimmunology & neuroinflammation},
  year={2014}
}
OBJECTIVES To describe the clinical course and neuropathology at autopsy of a patient with neuromyelitis optica (NMO) treated with alemtuzumab. METHODS Case report. RESULTS A 61-year-old woman with aquaporin-4 immunoglobulin G antibody seropositive NMO had 10 clinical relapses in 4 years despite treatment with multiple immunosuppressive therapies. Alemtuzumab was administered and was redosed 15 months later. For the first 19 months after the initial alemtuzumab infusion, the patient did not… CONTINUE READING
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