Mass transport of macromolecules within an in vitro model of supragingival plaque.

  title={Mass transport of macromolecules within an in vitro model of supragingival plaque.},
  author={Thomas Thurnheer and Rudolf Gm{\"u}r and Stuart Shapiro and Bernhard Guggenheim},
  journal={Applied and environmental microbiology},
  volume={69 3},
The aim of this study was to examine the diffusion of macromolecules through an in vitro biofilm model of supragingival plaque. Polyspecies biofilms containing Actinomyces naeslundii, Fusobacterium nucleatum, Streptococcus oralis, Streptococcus sobrinus, Veillonella dispar, and Candida albicans were formed on sintered hydroxyapatite disks and then incubated at room temperature for defined periods with fluorescent markers with molecular weights ranging from 3,000 to 900,000. Subsequent… CONTINUE READING


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