Mass transport in arteries and the localization of atherosclerosis.
@article{Tarbell2003MassTI,
title={Mass transport in arteries and the localization of atherosclerosis.},
author={John M Tarbell},
journal={Annual review of biomedical engineering},
year={2003},
volume={5},
pages={
79-118
}
}Atherosclerosis is a disease of the large arteries that involves a characteristic accumulation of high-molecular-weight lipoprotein in the arterial wall. This review focuses on the mass transport processes that mediate the focal accumulation of lipid in arteries and places particular emphasis on the role of fluid mechanical forces in modulating mass transport phenomena. In the final analysis, four mass transport mechanisms emerge that may be important in the localization of atherosclerosis…
270 Citations
MASS TRANSPORT IN ARTERIES AND THE LOCALIZATION OF ATHEROSCLEROSIS IN HUMAN
- Biology
- 2010
This research focuses on the mass transport processes that mediate the focal accumulation of lipid in arteries and places particular emphasis on the role of fluid mechanical forces in modulating mass transport phenomena as well as analysis of the Damkholer numbers within the arterial surfaces.
Computational Modelling of Mass Transport in Large Arteries
- Biology
- 2008
In the present study, mass transport of macromolecules in large arteries, as well as its relationships with fluid mechanics and localisation of atherosclerosis, was studied.
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This review begins with a brief overview of the molecular changes in vascular cells associated with hypoxia and then emphasizes the transport mechanisms that bring oxygen to cells within the vascular wall, focusing on fluid mechanical factors that control oxygen transport from lumenal blood flow to the intima and inner media layers of the artery.
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- 2014
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This paper supplements the well known four-layer arterial wall model to include two pressure induced effects: the compression of the intima tissue and the increase of the fraction of leaky junctions, and demonstrates that such model can reach the very good agreement with experimental data.
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