Mass spectrometry of oligonucleotides.

  title={Mass spectrometry of oligonucleotides.},
  author={Stefan Sch{\"u}rch and Jan M Tromp and Selina T M Monn},
  journal={Nucleosides, nucleotides & nucleic acids},
  volume={26 10-12},
Expanding research in the field of modified oligonucleotides demands suitable analytical tools for size and purity verification of known compounds and accurate structure elucidation of unknowns. There is a need for characterization of the types and sites of modifications in oligonucleotides and to identify and sequence selected candidates originating from synthesis. The potential of electrospray tandem mass spectrometry (ESI-MS/MS) for structural characterization and sequencing of… CONTINUE READING