Mass spectrometry measurements of prostate-specific antigen (PSA) peptides derived from immune-extracted PSA provide a potential strategy for harmonizing immunoassay differences.

@article{Klee2014MassSM,
  title={Mass spectrometry measurements of prostate-specific antigen (PSA) peptides derived from immune-extracted PSA provide a potential strategy for harmonizing immunoassay differences.},
  author={Eric W. Klee and Olga P. Bondar and Marcia K Goodmanson and Sergey A. Trushin and Ravinder Jit Singh and Nathaniel Anderson and George G. Klee},
  journal={American journal of clinical pathology},
  year={2014},
  volume={141 4},
  pages={527-33}
}
OBJECTIVES Harmonization of prostate-specific antigen (PSA) immunoassays is important for good patient care. The specificity of the antibodies used to detect circulating PSA could cause differences in the PSA measurements. METHODS We used mass spectrometry (MS) to quantitate the concentration of five peptides cleaved from trypsin digestion of PSA and compared these measurements with six automated immunoassays. Linear regression and a mixed-effects model were used to analyze the results… CONTINUE READING

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