Mass spectrometry in the quantitative analysis of therapeutic intracellular nucleotide analogs.

Abstract

Nucleoside analogs are widely used in anti-cancer, anti-(retro)viral, and immunosuppressive therapy. Nucleosides are prodrugs that require intracellular activation to mono-, di-, and finally triphosphates. Monitoring of these intracellular nucleotides is important to understand their pharmacology. The relatively involatile salts and ion-pairing agents… (More)
DOI: 10.1002/mas.20280

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Cite this paper

@article{Jansen2011MassSI, title={Mass spectrometry in the quantitative analysis of therapeutic intracellular nucleotide analogs.}, author={Robert S. Jansen and Hilde R. Rosing and Jan H. M. Schellens and Jos H. Beijnen}, journal={Mass spectrometry reviews}, year={2011}, volume={30 2}, pages={321-43} }