Mass spectrometry in the postgenomic era.

  title={Mass spectrometry in the postgenomic era.},
  author={B. Chait},
  journal={Annual review of biochemistry},
  • B. Chait
  • Published 2011
  • Biology, Medicine
  • Annual review of biochemistry
  • Mass spectrometry (MS) is rapidly becoming an essential tool for biologists and biochemists in their efforts to throw light on molecular mechanisms within cellular systems. Used in unison with genome sequence data, MS has developed into the method of choice for identifying proteins, elucidating their posttranslational modifications, and reading out their functional interactions. Variations of the method have even begun to enable accurate mass determination of intact protein complexes, allowing… CONTINUE READING
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