Mass spectrometry in the postgenomic era.

@article{Chait2011MassSI,
  title={Mass spectrometry in the postgenomic era.},
  author={B. Chait},
  journal={Annual review of biochemistry},
  year={2011},
  volume={80},
  pages={
          239-46
        }
}
  • B. Chait
  • Published 2011
  • Biology, Medicine
  • Annual review of biochemistry
  • Mass spectrometry (MS) is rapidly becoming an essential tool for biologists and biochemists in their efforts to throw light on molecular mechanisms within cellular systems. Used in unison with genome sequence data, MS has developed into the method of choice for identifying proteins, elucidating their posttranslational modifications, and reading out their functional interactions. Variations of the method have even begun to enable accurate mass determination of intact protein complexes, allowing… CONTINUE READING
    50 Citations

    Figures and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    A mass spectrometry view of stable and transient protein interactions.
    • 22
    Purification of a specific native genomic locus for proteomic analysis
    • 50
    • PDF
    Trends in ultrasensitive proteomics.
    • 113
    • PDF
    Mass spectrometry and animal science: protein identification strategies and particularities of farm animal species.
    • 56
    A Pipeline for Determining Protein–Protein Interactions and Proximities in the Cellular Milieu*
    • 33
    • PDF

    References

    SHOWING 1-10 OF 332 REFERENCES
    Phosphoproteomics for the masses.
    • 142
    Advances in the mass spectrometry of membrane proteins: from individual proteins to intact complexes.
    • 118
    • PDF
    The role of mass spectrometry in structure elucidation of dynamic protein complexes.
    • 311
    Quantitative, high-resolution proteomics for data-driven systems biology.
    • J. Cox, M. Mann
    • Biology, Medicine
    • Annual review of biochemistry
    • 2011
    • 584
    • PDF
    Mass spectrometry–based proteomics turns quantitative
    • 1,478
    • PDF
    Proteomics by mass spectrometry: approaches, advances, and applications.
    • 894
    • PDF
    The utility of ETD mass spectrometry in proteomic analysis.
    • 510
    Applications of mass spectrometry to lipids and membranes.
    • 146