Mass spectrometry in the analysis of N-linked and O-linked glycans.

  title={Mass spectrometry in the analysis of N-linked and O-linked glycans.},
  author={Simon J. North and Paul Hitchen and Stuart M. Haslam and Anne Dell},
  journal={Current opinion in structural biology},
  volume={19 5},
Mass spectrometry (MS) continues to play a vital role in defining the structures of N-glycans and O-glycans in glycoproteins via glycomic and glycoproteomic methodologies. The former seeks to define the total N-glycan and/or O-glycan repertoire in a biological sample whilst the latter is concerned with the analysis of glycopeptides. Recent technical developments have included improvements in tandem mass spectrometry (MS/MS and MS(n)) sequencing methodologies, more sensitive methods for… CONTINUE READING
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