Mass spectrometry imaging with laser-induced postionization

@article{Soltwisch2015MassSI,
  title={Mass spectrometry imaging with laser-induced postionization},
  author={Jens Soltwisch and Hans Kettling and Simeon Vens-Cappell and Marcel Wiegelmann and Johannes M{\"u}thing and Klaus Dreisewerd},
  journal={Science},
  year={2015},
  volume={348},
  pages={211 - 215}
}
Imaging lipid composition Chemical imaging of cell membranes can be performed with matrix-assisted laser desorption/ionization mass spectrometry (MALDI), but low ionization efficiency often leads to a signal dominated by the main lipid components, such as abundant phosphatidylcholine species. Soltwisch et al. used a tunable laser for post-ionization of neutral species to boost the signal for other membrane components, such as cholesterol and phospho- and glycolipids. Imaging of cells and… Expand
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