Mass-spectrometry based minisequencing method for the rapid detection of drug resistance in Mycobacterium tuberculosis.

Abstract

A MALDI TOF MS based minisequencing method has been developed and applied for the analysis of rifampin (RIF)- and isoniazid (INH)-resistant M. tuberculosis strains. Eight genetic markers of RIF resistance-nucleotide polymorphisms located in RRDR of rpoB gene, and three of INH resistance including codon 315 of katG gene and -8 and -15 positions of the… (More)

Topics

Cite this paper

@article{Ikryannikova2007MassspectrometryBM, title={Mass-spectrometry based minisequencing method for the rapid detection of drug resistance in Mycobacterium tuberculosis.}, author={L N Ikryannikova and Maxim V Afanas'ev and Tat'yana A Akopian and Elena N Il'ina and Aleksey V Kuz'min and Elena E. Larionova and Tat'yana G Smirnova and Larisa N. Chernousova and Vadim M. Govorun}, journal={Journal of microbiological methods}, year={2007}, volume={70 3}, pages={395-405} }