Mass spectrometry as a diagnostic and a cancer biomarker discovery tool: opportunities and potential limitations.

@article{Diamandis2004MassSA,
  title={Mass spectrometry as a diagnostic and a cancer biomarker discovery tool: opportunities and potential limitations.},
  author={Eleftherios P Diamandis},
  journal={Molecular & cellular proteomics : MCP},
  year={2004},
  volume={3 4},
  pages={367-78}
}
Serum proteomic profiling, by using surfaced-enhanced laser desorption/ionization-time-of-flight mass spectrometry, is one of the most promising new approaches for cancer diagnostics. Exceptional sensitivities and specificities have been reported for some cancer types such as prostate, ovarian, breast, and bladder cancers. These sensitivities/specificities are far superior to those obtained by using classical cancer biomarkers. In this review, I concentrate more on questions that cast doubt on… CONTINUE READING
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