Mass spectrometry: from proteomics to metabolomics and lipidomics.

@article{Griffiths2009MassSF,
  title={Mass spectrometry: from proteomics to metabolomics and lipidomics.},
  author={William J. Griffiths and Yuqin Wang},
  journal={Chemical Society reviews},
  year={2009},
  volume={38 7},
  pages={
          1882-96
        }
}
Mass spectrometry (MS) in combination with liquid chromatography (LC), i.e. LC-MS, is the key analytical technique on which the emerging "omics" technologies of proteomics, metabolomics and lipidomics are based. It provides both structural and quantitative data and can be used in a "global" or "targeted" manner allowing on the one hand the identification of thousands of proteins from a tissue, or on the other the detection of biologically active metabolites at levels of a few parts-per-billion… 
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238 Citations
Highly Influential Citations
6
Background Citations
64
Methods Citations
29

238 Citations

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The main advances in the MS technologies are focused on, influencing genomics, transcriptomics, proteomics, lipidomics and metabolomics fields, up to the most recent MS applications to meta-omic studies.

Current state-of-the-art of nontargeted metabolomics based on liquid chromatography-mass spectrometry with special emphasis in clinical applications.

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TLDR
This paper will review the different mass spectrometry-based proteomic and lipidomic strategies applied in cardiovascular diseases, especially atherosclerosis, with particular attention given to recent developments and the role of bioinformatics in data treatment.

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This chapter provides a glimpse at the current status of the mass spectrometry-based metabolomics field highlighting the opportunities and challenges.

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Targeted metabolomics for biomarker discovery.

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This Review highlights important technical prerequisites as well as recent developments in metabolomics and metabolomics data analysis with special emphasis on their utility in biomarker identification and qualification, aswell as targeted metabolomics by employing high-throughput mass spectrometry.
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