Mass spectrometry: come of age for structural and dynamical biology.

  title={Mass spectrometry: come of age for structural and dynamical biology.},
  author={Justin L P Benesch and Brandon T Ruotolo},
  journal={Current opinion in structural biology},
  volume={21 5},
Over the past two decades, mass spectrometry (MS) has emerged as a bone fide approach for structural biology. MS can inform on all levels of protein organization, and enables quantitative assessments of their intrinsic dynamics. The key advantages of MS are that it is a sensitive, high-resolution separation technique with wide applicability, and thereby allows the interrogation of transient protein assemblies in the context of complex mixtures. Here we describe how molecular-level information… CONTINUE READING

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